Cellular fatty acid uptake: a pathway under construction
نویسندگان
چکیده
منابع مشابه
Mechanism of cellular fatty acid uptake.
circulation and represent an important, readily available energy source for certain organs like liver and heart. Controversy exists over how they are translocated across the plasma membrane [ 13. Since albumin is not taken up into the cells, only the dissociated unbound fatty acids are available for uptake. For evaluation of whether this uptake occurs by simple diffusion or facilitated transpor...
متن کاملOleic acid uptake and binding by rat adipocytes define dual pathways for cellular fatty acid uptake.
Oleic acid (OA) uptake by rat adipocytes and the proportions of intracellular unesterified [3H]OA and its 3H-labeled esters were determined over 300 s. Uptake was linear for 20;-30 s, with rapid esterification indicating entry into normal metabolic pathways. Initial rates of OA uptake and its binding to plasma membranes were studied over a spectrum of oleic acid:bovine serum albumin (BSA) ratio...
متن کاملEnterocyte fatty acid uptake and intestinal fatty acid-binding protein.
This article reviews our current understanding of the uptake of fatty acids by the enterocytes of the intestine. The micellar solubilization of fatty acids by bile salts and the factors regulating that process are discussed. The mechanism of how micellar solubilization of fatty acids promotes the uptake of fatty acids by enterocytes and their relative importance is reviewed. Additionally, discu...
متن کاملMyocardial and Hepatocellular Fatty Acid Uptake
Fatty acid influx into human myocardium was studied in 15 patients during the cooling phase of cardiopulmonary bypass at myocardial temperatures of 370 to 25°C. The fitting of the data to a functional relation, developed in this study, revealed fatty acid influx to be a temperature-dependent saturable process corresponding to a Michaelis-Menten constant (K.) at 370C of 0.26±0.084 ,umol/g, a max...
متن کاملFatty acid uptake in normal human myocardium.
Fatty acid binding protein has been found in rat aortic endothelial cell membrane. It has been identified to be a 40-kDa protein that corresponds to a 40-kDa fatty acid binding protein with high affinity for a variety of long chain fatty acids isolated from rat heart myocytes. It is proposed that this endothelial membrane fatty acid binding protein might mediate the myocardial uptake of fatty a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Endocrinology & Metabolism
سال: 2009
ISSN: 1043-2760
DOI: 10.1016/j.tem.2008.11.001